Topps entertainment cards and stickers began with Hopalong Cassidy, Davey Crockett and Elvis Presley in the 1950s. Subsequent series included the Beatles, Star Trek, Star Wars, E.T. and Michael Jackson. More recent hits have been Goosebumps, The X-Files and Animaniacs.

From time to time, the company has also created products parodying popular fads and recognized products. These products have included Nasty Valentines, Wacky Packages and Garbage Pail Kids. The Mars Attacks! science fiction trading cards and comic book became a motion picture in 1996, released by Warner Bros.